Why does your lab need XiltriX

In the field of In Vitro Fertilization (IVF) and Assisted Reproductive Technology (ART), consistency, traceability, and reliability are essential for achieving successful outcomes. The laboratory is where most operational risks originate, it is the core of the IVF process, where embryos, oocytes, sperm, and cryopreserved material are handled under tightly controlled conditions. Even minor deviations in temperature, gas concentrations, humidity, air quality, or cryogenic storage conditions can impact laboratory performance and introduce unnecessary risks.

Maintaining continuous control over the laboratory environment is therefore essential. Strict adherence to Standard Operating Procedures (SOPs), combined with real-time oversight of critical equipment and environmental parameters, helps safeguard valuable biological material, reduce variability, support accreditation requirements, and prevent disruptions to critical workflows.

XiltriX International supports IVF and ART laboratories worldwide with a fully managed, real-time Monitoring-as-a-Service platform specifically optimised for reproductive medicine. The XiltriX platform provides continuous monitoring, alarming, reporting, and proactive risk mitigation across all critical laboratory environments, equipment, and cryogenic storage facilities. Combined with 24/7 expert support and configurable alarm escalation pathways, XiltriX delivers a compliant and highly reliable monitoring infrastructure for safe and continuous IVF operations.

XiltriX SaaS Platform

The XiltriX SaaS Platform provides IVF laboratories with a secure and highly reliable foundation for real-time monitoring, alarm management, reporting, and compliance. By utilizing a centrally managed SaaS infrastructure, laboratories benefit from automated platform updates, automated backups, cybersecurity management, and high system availability without placing additional burden on local IT resources.

As an ISO-9001:2015 and ISO-27001:2022 certified organization, XiltriX ensures the highest standards for Quality, Information Security, Data Integrity, Access Control, and Business Continuity. This allows IVF laboratories to focus on patient care and laboratory operations, while XiltriX safeguards the monitoring infrastructure that protects their most valuable assets.

Monitoring hardware with redundant communication and power

For sensor measurement and communication to the platform, XiltriX provides purpose-built hardware with triple redundant communication options (LAN, Wi-Fi and 4G) and a big rechargeable backup battery to keep measurements, data acquisition and notifications flowing even when everything else fails. This fleet of hardware is remotely monitored and can be updated via an automated OTAU (Over the Air Update) process limiting the need for physical interactions and disturbances in your laboratory.

XiltriX Key Benefits

Continuous Availability
The XiltriX SaaS Platform is hosted within a secure and redundant cloud infrastructure, providing continuous access to monitoring data, alarms, and reports. Built-in redundancy and professional infrastructure management maximize system availability and reliability.

Anywhere Access
Authorized users can securely access real-time data, trends, reports, and alarm information from any location with an internet connection. This provides complete visibility of laboratory operations, whether managing a single site or multiple IVF facilities.

Native Mobile Support
The Saas Platform can be securely accessed through any mobile device (phone or tablet) and is optimised for touch screens. The authentication allows for SSO (Single Sign On) with MFA.

Automatic Alarm Escalation
Users are automatically notified of any deviation via cascading WhatsApp, SMS or Email notification programs or local physical alarms (beacons or sirens).

Comprehensive Audit Trail
All measurements, alarms, acknowledgements, user actions, and events are automatically recorded and securely stored. Any historical data can be retrieved instantly to support audits.

Scalable & Future-Proof
The platform is designed to grow with your organization, supporting everything from a single IVF laboratory to large multi-site fertility groups operating across multiple locations and countries.

24/7 Expert Support Included

A monitoring service is only as reliable as the support structure behind it. XiltriX therefore combines its SaaS Platform with continuous technical oversight and expert assistance, ensuring laboratories remain protected around the clock.

Proactive System Monitoring
Continuous health diagnostics of the monitoring infrastructure help identify and resolve potential issues before they impact system performance or availability.

Remote Updates, Configuration & Deployment
System updates, expansions, alarm modifications, user management, and configuration changes can be implemented remotely, reducing response times and operational overhead.

 Local Installation & Field Support
On-site installation, calibration, maintenance, and logistical support are provided through XiltriX and its network of certified local partners, ensuring professional assistance wherever required.

Cryo Room

Cryogenic storage is one of the most critical areas within an IVF laboratory. Embryos, oocytes, and sperm are stored at -196°C temperatures where even slight changes in liquid nitrogen supply, pressure, or insulation integrity can lead to irreversible viability damage. Continuous, real-time independent monitoring is therefore essential to ensure long-term sample safety, full compliance with regulatory standards and to provide time to prevent damage before instead of repairing it.

XiltriX provides comprehensive cryogenic monitoring solutions that safeguard each vessel, track consumption patterns, and ensure safe working conditions for staff.

Key Monitoring Parameters:

Minimum LN₂ Level by Temperature
Measures true liquid nitrogen levels inside the vessel, ensuring samples remain fully submerged and never exposed to unsafe temperatures.

External Temperature Sensors
A neck-mounted probe detects insulation or vacuum failure within seconds, enabling immediate intervention before heat intrusion affects sample viability.

Weight / Scale Monitoring
Tracking the weight of cryo tanks reveals LN₂ consumption rates. Alerts are triggered when the tank becomes too light, helping prevent unexpected depletion.

Low-Pressure Vessel Level Monitoring (C-Stic)
Measures internal level in low-pressure LN₂ vessels, providing an additional layer of protection for sensitive biological material. Provides remote visibility of liquid Nitrogen supply and consumption.

Oxygen Depletion Monitoring (Cryo Room)
LN₂ leaks or displacement events can rapidly reduce oxygen levels. XiltriX continuously monitors O₂ concentration in the cryo room, protecting personnel from asphyxiation risks and ensuring a safe working environment.

Many modern cryogenic storage facilities use centralized liquid Nitrogen supply systems and automated filling technologies to improve efficiency and reduce manual intervention. While these systems offer significant operational benefits, they also introduce additional points of failure that require continuous supervision. XiltriX integrates directly with the cryogenic infrastructure, providing real-time visibility of vessel status, liquid nitrogen availability, filling performance, and supply conditions to ensure uninterrupted protection of valuable biological samples.

CryoFill Controller Integration
Full integration with CryoFill enables continuous monitoring of LN₂ temperature, levels, and fill cycles. XiltriX issues immediate alarms for fill failures or abnormal consumption, essential for automated cryo systems. Without this kind of information, the risks of vessels running out of liquid Nitrogen is much greater, as temperatures will only start to rise when all liquid Nitrogen has evaporated.

Cryo Room Safety Display

Highly visible status displays installed at the entrance of the cryogenic storage area provide an immediate sign of room safety. Using clear color-coded status indicators (Green = Safe, Red = Not Safe), personnel can instantly assess whether it is safe to enter the room without needing to consult the monitoring software. This provides an additional layer of protection during both normal operation and emergency situations.
Liquid Nitrogen is inert, colorless, and odorless, making Oxygen depletion one of the most significant safety risks in cryogenic storage areas. Even a relatively small LN₂ leak can rapidly displace oxygen within a poorly ventilated room, creating a potentially life-threatening environment without any visible warning signs. Continuous oxygen monitoring is therefore essential to protect personnel, support safe laboratory operations, and follow occupational health and safety requirements.

Box-Type Incubators

Box-type incubators are essential to IVF laboratories, providing a stable, controlled environment needed for embryo development. These units continuously regulate temperature, CO₂, O₂, and humidity, making them highly sensitive to even minor fluctuations. Any deviation in these parameters can directly affect embryo viability, culture quality, and overall clinical outcomes.

XiltriX delivers independent, real-time monitoring for box-type incubators to ensure full oversight of these critical systems. By verifying true chamber conditions using external, high-accuracy sensors and immediate alarm escalation, XiltriX helps prevent environmental drift, equipment failures, and undetected issues that could compromise the culture environment.

Key Monitoring Parameters:

Temperature Sensors
High-accuracy Pt100 probes confirm stable internal temperature and detect deviations caused by heater malfunction or prolonged door openings.

CO₂ / O₂ Monitoring
Independent NDIR CO₂ sensors and high accuracy O₂ sensors verify true chamber conditions and detect drift or calibration issues early.

Humidity Monitoring
Stable humidity prevents evaporation and keeps proper osmolarity. XiltriX monitors humidity trends to identify under-humidification or system failures.

Door Sensors
Door sensors correlate openings with recovery times and help reduce unnecessary fluctuations in chamber conditions.

Power Failure Monitoring
Immediate alerts for local power loss or device shutdown allow rapid intervention before environmental conditions drift.

Custom Integrations
Depending on model and available interfaces, XiltriX can monitor global alarms, power status, CO₂/O₂ levels, humidity, and chamber temperature across most box-type systems.

Benchtop Incubators

Benchtop incubators are increasingly used in IVF laboratories due to their compact footprint, rapid recovery times, and chamber-based design. Each compartment functions as an isolated micro-environment, often supporting multiple patients simultaneously. Because of their small volume and sensitivity, benchtop incubators can experience rapid fluctuations in temperature, CO₂ and O₂, making reliable monitoring essential.
Many benchtop models are “closed systems,” meaning internal access is limited and door seals must never be compromised. XiltriX offers safe, vendor supported integration methods that monitor chamber conditions, detect alarm states, and track power status without interfering with the incubator’s performance. Some suppliers even provide built-in validation or monitoring ports that allow direct, independent connection to an external monitoring system, a feature XiltriX can use where available. This approach preserves the integrity of door seals and internal airflow while still providing full alarm visibility.

Key Monitoring Parameters:

Temperature Monitoring
Temperature stability is the most critical factor in benchtop incubators. XiltriX monitors individual chamber temperatures through built-in sensors when available.

This enables early detection of drift, heater malfunction, or delayed recovery after access, particularly important in multi-drawer systems where each compartment behaves independently. XiltriX holds stock of many custom cables and connectors needed to connect to these incubators making integration effortless for lab users.

CO₂ / O₂ Monitoring
Where supported by the manufacturer, XiltriX integrates directly with CO₂ and O₂ outputs or communication ports to verify gas stability across individual chambers. This ensures correct pH conditions and environment consistency throughout all compartments.

Alarm Output Integration
For benchtop incubators that limit internal access, XiltriX connects via digital alarm outputs to safely capture critical alerts, generally including: Over-/under-temperature, High/low CO₂ or O₂, Low humidity.

Fridges & Freezers

Fridges and freezers play a critical role in IVF laboratories, supporting the safe storage of media, consumables, calibration materials, and temperature-sensitive reagents. While refrigerators typically operate at 4°C, freezers may run at –20°C, –30°C, –40°C, or –80°C, depending on their purpose. Not all labs use fit-for-purpose cooling equipment, making it even more critical to keep track of the cooling performance.
Because temperature (both thawing and freezing) deviations can compromise product integrity or delay essential procedures, continuous, independent monitoring is essential.

Key Monitoring Parameters:

Temperature Sensors

High-accuracy Pt100 sensors verify the true internal temperature, independent from the device’s own display, ensuring that all materials are kept within the required range for stability and performance.

Door Sensors

Door sensors detect when a refrigerator or freezer is opened. This helps correlate temperature fluctuations with user activity, prevent unnecessary alarms, and alert staff if a door is left open long enough to risk warming.

Alarm Output Integration

XiltriX can read the device’s internal alarm signal to capture general alerts such as compressor issues, high-temperature warnings, blocked filters, or sensor malfunctions. Adding an additional layer of protection.

Power Failure Monitoring

Instant detection of local power loss allows corrective actions long before the unit’s internal temperature begins to rise. This is especially critical for –80°C ULT freezers, where early power notifications can prevent hours of manual recovery or potential product damage.

Air Quality

Air quality is a defining factor in the performance, consistency, and safety of an IVF laboratory. Sensitive biological materials react rapidly to changes in temperature, humidity, and airborne contaminants. Maintaining a stable, clean, and homeostatic environment is essential for embryo culture, cryogenic workflows, and overall laboratory performance.

XiltriX monitors critical environmental parameters continuously, ensuring that deviations are detected early and corrective actions can be taken before they affect laboratory operations.

Key Monitoring Parameters:

Temperature & Relative Humidity (T&RH) Sensors

These sensors ensure that ambient conditions remain within defined limits. Fluctuations in ambient temperature or humidity can affect media stability, incubator performance, evaporation rates, and even equipment calibration. Continuous monitoring ensures the room environment supports consistent lab performance.

VOC Monitoring

Volatile Organic Compounds can originate from cleaning agents, paint, plastics, furniture, construction materials, and even outside air. IVF laboratories are particularly sensitive to VOC exposure, as many VOCs are detrimental to embryo viability. By detecting VOC levels in real time, XiltriX helps maintain safe air quality and ensures compliance with recommended IVF air standards.

Differential Pressure Monitoring

IVF laboratories rely on cleanroom-style airflow patterns where air moves from cleaner to dirtier zones. Differential pressure sensors monitor the pressure difference between rooms to verify that the pressure balance is maintained correctly. This prevents unfiltered air, microorganisms, and particulates from entering critical areas and protects embryos from airborne contamination.

Particle Counting

In laboratories requiring classification under ISO 14644 or cleanroom protocols, XiltriX can digitally integrate laser-based particle counters. These devices measure particle concentrations (e.g., ≥ 0.5 μm) to verify cleanroom performance and quickly identify filtration or airflow issues.

Air Handling Unit (AHU)

Integration For facilities with dedicated HVAC controls, XiltriX can connect to BMS or AHU systems to correlate environmental drift with equipment behaviour, supporting root-cause analysis and preventive maintenance. Airflows can be monitored as well as the air exchanges for a room per hour.

Gas Manifolds

Gas manifolds play a vital role in IVF laboratories by supplying stable, uninterrupted CO₂, N₂, and mixed gas to incubators, workstations, and other critical equipment. The reliability of this system directly affects culture conditions, meaning any fluctuations in pressure or flow can influence pH stability, gas delivery, and overall equipment performance. Selecting the right manifold and failover system, with proper monitoring capabilities, is essential for maintaining consistent laboratory conditions. XiltriX provides comprehensive monitoring options for gas manifolds to ensure continuous supply, early detection of anomalies, and full oversight of critical gas delivery systems.

Key Monitoring Parameters:

Ambient Gas Monitoring (O₂ / CO₂ Safety Monitoring)

Monitors Oxygen (O₂) and Carbon Dioxide (CO₂) concentrations within the gas cylinder storage room to protect personnel and provide early detection of gas leaks. Oxygen sensors detect Oxygen depletion caused by leaking nitrogen cylinders or cryogenic systems, while CO₂ sensors identify elevated carbon dioxide levels resulting from leaking cylinders, regulators, or manifold components. Real-time monitoring and alarming ensure that unsafe conditions are detected immediately, allowing corrective action before personnel safety is compromised.

Gas Flow Sensors
Track the flow of gases through the manifold to ensure consistent supply to incubators and other devices. Deviations may indicate leaks, blockages, or consumption abnormalities.

Inline Gas Pressure Monitoring
Precise pressure is essential for stable incubator performance. Inline pressure sensors verify that each gas line maintains the correct pressure, helping prevent fluctuations that could impact pH control or environmental stability.

Dry Contacts / 4–20 mA Outputs
Digital gas manifolds often provide alarm outputs or analogue signals for remote monitoring of level, pressure, and automatic switchover events. XiltriX integrates seamlessly with these signals, allowing early detection of: Empty cylinders, Pressure drops, Failed switchover, Regulator or valve malfunctions. When selecting a manifold, it is important to confirm which digital outputs are available so the most critical parameters can be integrated into XiltriX.

API Connectivity

Modern IVF laboratories rely on multiple digital platforms to manage patient data, maintain chain-of-custody, and oversee facility infrastructure. XiltriX integrates effortlessly with these systems, ensuring that monitoring data becomes an active part of the workflow rather than an isolated layer. This creates a unified information ecosystem that strengthens compliance, traceability, and operational efficiency.

Key Integration Options Include:

XiltriX visualization Screens
XiltriX provides visualization screens that provide real-time data to users in many form factors. Small flush mounted or large wall mounted solution show data that is automatically retrieved through the XiltriX API and show values and statuses of all desired parameters.

Electronic Medical Records (EMR)
XiltriX provides the ability to retrieve any information from its database on the fly. This functionality allows for: Automatic documentation of incubator conditions during culture, Traceable links between environmental stability clinical decisions, Improved compliance for audits, accreditation, and regulatory inspections, Integrating EMR with XiltriX reduces manual logging, minimizes human error, and enhances data completeness.

Building Management Systems (BMS)
XiltriX can deliver real-time sensor data directly to facility-level control platforms. Relevant data includes temperature, humidity, differential pressure, VOC, and power status. These integration allow for: Unified dashboards of environmental conditions across both the IVF lab and broader facility, Faster detection of HVAC or utility issues affecting lab performance, Improved coordination between lab, QA, and technical services. By integrating XiltriX with BMS systems, laboratories ensure that facility managers receive the same high-resolution data used by clinical staff.

Witness Systems (Chain-of-Custody Platforms)
Witness systems verify identity, track sample handling, and document every interaction with biological material. XiltriX supports these workflows by providing just in time environmental and alarm data, helping laboratories: Link handling events with exact incubator or lab conditions, Support chain-of-custody traceability, Document compliance with SOPs during critical steps. This information flow integration provides a more complete picture of what happened during a patient cycle.

API & Custom Integrations
XiltriX provides an API that enables third-party systems to securely retrieve both real-time and historical monitoring data. This users to build custom integrations, dashboards, and workflows tailored to their specific operational requirements. Typical applications include: Custom alarm visualization platforms displaying active alarms across multiple locations in real time, Centralized monitoring dashboards for laboratory networks and hospital groups, Integration with internal reporting and business intelligence tools, Automated data exchange with quality management and compliance platforms, Custom notifications, workflows, and escalation procedures. By providing secure API access, XiltriX ensures that monitoring data is not limited to a single interface but can become an integral part of the laboratory’s wider digital ecosystem.

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